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BRIC doctoral programme: Training projects
This programme aims to improve the supply of skills to industry and academia in the bioprocessing sector, by providing a PhD programme that includes structured training that exposes students to industrial practices and needs. Our vision is to provide PhD students with a first-rate, challenging research training experience within the context of a mutually beneficial research collaboration, between academic and partner organisations.
At the heart of the programme is a research training project which provides the student with the opportunity to:
- make a novel contribution to industrially relevant research in bioprocessing
- gain exposure to the challenges facing industrial companies in this sector
For an overview of BRIC projects in the UK see 'Google: BRIC Projects map' in external links.
A third call was launched in August 2012 (proposal deadline: 11 October 2012). This programme may award up to 10 studentships in partnership with BRIC member companies. Further details can be found in the 'BRIC doctoral programme' section.
A second call was launched in October 2011 and awarded 10 studentships in the bioprocessing area.
- Simplified in-process detection of protein higher order structure and aggregation
- Analysis of protein secretion bottlenecks in Pichia pastoris
- Unraveling the relationship between IgG yield, recovered/observed clonal numbers and specific integration site on the yield of IgG in CHO cells
- The development of Raman spectroscopy for online monitoring of industrial bioprocesses
- Application of arginine glutamate in protein bioprocessing and formulation
- Development and optimisation of a high-throughput profiling platform for assessment of recombinant protein structural variants
- Development of novel bacterial 'bioreactor' organelles for authentic synthesis and PTMs of mammalian recombinant proteins
- An investigation into the immunogenicity of human therapeutic proteins
- Development of novel methods for periplasmic release of biotherapeutic products
- Engineering cells for antibody production
The first call awarded 8 studentships in partnership with BRIC member companies.
- Linking high throughput cell culture multivariate analysis and economics for more effective process integration
- Microscale freeze-dried and liquid formulations of therapeutics to investigate the relationship between forced degradation and long-term shelf life
- Understanding on-column protein aggregation and its impact on bioprocessing
- Controlling liquid-liquid phase separation in antibody formulations
- Protein burden in protein overproduction
- Development of a computational tool for predicting the impact of bioprocess conditions on protein glycosylation
- Development of single molecule assays for the detection of aggregation within high concentration protein therapeutics
- An upstream platform for the production of high grade heterologous proteins in Pichia pastoris
BRIC skills development school
BRIC students are given a unique opportunity to attend the BRIC skills development school.
This is open to BRIC PhD students and early career post-docs to learn industrially relevant techniques and transferable skills from a training program devised by BRIC industrial members.
The students take part in an intensive, week-long course which aims to develop the skills they require to drive the growth of the bioprocessing industry. The school, hosted by a BRIC industry member, provides students with an insight into the challenges that face the bioprocessing industry and shows how these problems can be overcome. BRIC students are contacted about attendance at an appropriate stage during their projects.
See also: Bioprocessing researchers go back to school to read our news item about this school.
Andrew Staphnill, Business Interface Manager
tel: 01793 444287