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BRIC2: Research projects

A second phase of BRIC, BRIC2, was launched in March 2010 with a further £10M over 5 years from BBSRC, EPSRC and industry members. The second call phase of BRIC2 is now closed to applications. The remaining £6M will be invested in research projects and activities in the bioprocessing area in November 2012.

BRIC2 research investment has been targeted in the following priority areas:

• Bioprocessing challenges for protein and their host cell producers
• High-throughput bioprocess development
• Effective modelling of whole bioprocesses
• Robust and effective analytics for bioprocessing
• Bioprocessing research for cellular products

Funding available for research projects will be awarded through 2 rounds of funding

Further details of all of these awards are available in the downloads section.

2012 call

Invitations for full proposals from the outline stage were submitted by 26 June 2012 for allocation of remaining BRIC2 funding. The remaining £6M will be invested in research projects and activities in the bioprocessing area in November 2012. 

2010 call

In 2010 applications were received to the first round of BRIC phase 2, which included:

• Standard BRIC research grants - £3.7M was awarded
• Shorter enabling fund grants - £421k was awarded

BRIC research grants

1. Bioprocessing research for cellular products
2. Developing generic scalable and standardised selection methods for human therapeutic cells
3. A platform for the optimisation of metabolic pathways for glycosylation to achieve a narrow and targeted glycoform distribution
4. Elucidating aggregation mechanisms in antibody fragment-based therapeutics to improve their manufacturability
5. Predictable protein production
6. Understanding and predicting aggregation in biopharmaceuticals

Enabling fund grants

1. Cold chain storage and distribution of therapeutic mammalian cell cultures, including stem cells, using sol-gel technology
2. Microfabricated cantilever methods as nanoscale screens for early indicators of protein aggregation; a feasibility study
3. Systems optimisation of host cell tRNA usage and codon decoding for the improvement of bioprocessing parameters
4. Real time flux modelling in biopharmaceutical bioprocessing
5. De novo sequencing of the Chinese Hamster Ovary (CHO) cell genome

BRIC Doctoral Programme

Applications were also received for the first round of the BRIC doctoral programme which awarded eight studentships in partnership with BRIC member companies.

A second round of applications for the BRIC doctoral programme was launched in October 2011 and awarded an additional 10 studentships in the bioprocessing area.

A third round of applications for the BRIC Doctoral Programme was launched in August 2012 and close on the 11 October 2012. This programme may award up to an additional 10 studentships in partnership with BRIC member companies. Further details can be found in the 'BRIC doctoral programme' section.

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