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Fast-track arms race drives effective immune system

Visit  The University of Edinburgh website

23 October 2009

Our immune systems are locked in an arms race with infections and rapidly develop defences against their invaders, research suggests.

Scientists, part funded by BBSRC, found that, over many generations, those genes linked to immunity in the front line of defence have to evolve almost ten times faster than normal in order to keep disease at bay.

The study from the University of Edinburgh shows for the first time how fast the immune system has to change to keep up.

Immune systems and infections are locked in an evolutionary arms race – in which each side continually evolves new ways of attack and counter-attack. This study showed that overall, genes linked to immunity develop twice as fast as other genes, with those genes in the front line of defence adapting nearly ten times faster.

The study pinpoints genes that are most affected by this arms race, and will give scientists a greater understanding of how infections and immunity genes develop in tandem.

The research, published in PLoS Genetics, was carried out in collaboration with the Universities of Sheffield and Cambridge and, in addition to BBSRC, was supported by the Wellcome Trust and the Royal Society.

Dr Darren Obbard, of the School of Biological Sciences, said: “We knew that some immunity genes changed faster than others, but this is the first time we’ve really been able to quantify how much faster.”

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Dr Darren Obbard, School of Biological Sciences

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