Breeder’s tool kit to boost sustainable wheat farming
24 May 2011
A new project being led by the John Innes Centre, which receives strategic funding from BBSRC, is to develop a 'breeder's tool kit' that will help breed wheat varieties that produce higher quality flour and reduce wastage, boosting the economic and environmental sustainability of wheat farming in the UK. Working with four breeding companies (RAGT, Limagrain, KWS and Lantmännen SW Seed) and the HGCA will ensure that this toolkit will be exactly what is needed to drive discoveries from fundamental research into improved varieties.
A harvested wheat crop is normally assessed for several quality attributes that influence the ability of its flour to make bread and also affect the money paid to farmers by millers. One such parameter is called Hagberg Falling Number (HFN), which is an indirect measure of the properties that a loaf of bread will have. For example, wheat with low HFN will produce poor quality bread that is very difficult to slice because of sticky crumb.
Millers and other end-users avoid buying wheat grain that has a HFN value below a fixed number. In the last decade, an average of 28% of UK wheat grown for bread has failed to make the grade, and instead was sold for animal feed, which attracts a significantly lower price.
BBSRC, the Department for Environment, Food and Rural Affairs (Defra) and HGCA, the cereals and oilseeds division of the Agriculture and Horticulture Development Board (AHDB) are funding a LINK project that will apply the latest scientific knowledge to developing varieties with consistently high HFN.
What determines the HFN of wheat isn't fully understood, but it is heavily influenced by environmental conditions. Cold wet periods in the summer are thought to promote pre-harvest sprouting and reduce HFN, and the unpredictability of the UK climate makes predicting or controlling HFN very difficult. Wheat found to have too low an HFN for bread-making reduces efficient use of resources and contributes to waste in the food chain. Farming practices and management aren't able to reduce the effect of the climate, so there has been much interest in selecting varieties through plant breeding, but this has been hampered by a lack of knowledge about genetic factors that influence HFN.
Previous work involving Rothamsted Research, the JIC , University of Nottingham, Harper Adams University College and a large industrial consortium, which was also funded by Defra-BBSRC-HGCA LINK, took the first steps in discovering regions of the wheat genome that affect HFN. The new project will take this and use it to develop a 'breeder's tool kit' that will allow the four breeding partners to exploit this new knowledge of the genome to produce varieties with consistently higher HFN. This will involve using latest technologies to hone in on the regions, to provide genetic maps that breeders can use to navigate the wheat genome and focus breeding efforts on identifying the genes affecting HFN. The researchers will investigate how these genetic regions affect other important traits, such as yield, and how best the different regions can be combined to work together to produce high HFN values which would be independent of weather conditions.
The £1.34M 4 year project started in November 2010 and is funded by Defra, BBSRC and HGCA. Project partners include RAGT, Limagrain, KWS and Lantmännen SW Seed.
BBSRC is the UK funding agency for research in the life sciences. Sponsored by Government, BBSRC annually invests around £470M in a wide range of research that makes a significant contribution to the quality of life in the UK and beyond and supports a number of important industrial stakeholders, including the agriculture, food, chemical, healthcare and pharmaceutical sectors.
BBSRC provides institute strategic research grants to the following:
- The Babraham Institute
- Institute for Animal Health
- Institute of Biological, Environmental and Rural Sciences (Aberystwyth University)
- Institute of Food Research
- John Innes Centre
- The Genome Analysis Centre
- The Roslin Institute (University of Edinburgh)
- Rothamsted Research
The Institutes conduct long-term, mission-oriented research using specialist facilities. They have strong interactions with industry, Government departments and other end-users of their research.
11 October 2005
The following stories appear in the October 2005 edition of Business, the quarterly magazine of research highlights from the Biotechnology and Biological Sciences Research Council (BBSRC).
Scientists have developed a new technique that helps make pesticides more effective by removing insects’ ability to exhibit resistance. Their research will extend the effective life of current pesticides, reduce the amount that needs to be sprayed and remove the need for farmers to move to stronger and more harmful chemicals. The new technique relies on applying a chemical to block the insect’s processes that can degrade a pesticide. With the pests newly rendered helpless farmers can apply pesticide to kill them.
Dr Graham Moores, Rothamsted Research, Tel: 01582 763133 ext 2483, e-mail:email@example.com
Fruit fly studies open new avenue in cancer research
Researchers have discovered a family of amino acid transporters that are powerful growth promoters in fruit flies. When the transporters were overexpressed in a fly, its cells became hypersensitive to insulin-like molecules in the body that have a long-term role in promoting cell growth in development and cancer, and the cells grew excessively. If the equivalent genes in humans have the same effect then this discovery could lead to new drugs or even dietary advice that could block their activity and slow down the growth of tumours.
Dr Deborah Goberdhan, University of Oxford, Tel: 01865 282662, e-mail: firstname.lastname@example.org
Gene delivery vehicle for skeletal regeneration
UK scientists are working on new methods to regenerate cartilage and bone by delivering genes to stem cells within the body to instruct them to turn into bone cells. The new research will use tiny nanoscopic systems that cross the surface of a stem cell and then deliver the genes into that prompt the cell to turn into a bone cell. This method of gene delivery could provide significant healthcare benefits as trauma, degenerative disease and bone loss with old age all lead to patients needing orthopaedic procedures that require new bone.
Professor Richard Oreffo, University of Southampton, Tel: 023 8079 8502, e-mail: email@example.com
'Ending up' with antibody production
Scientists are pioneering a new technique to produce large numbers of antibodies quickly and reliably and this is being used to help the study of dangerous bacteria. The new technique harnesses the unique properties of the C-terminus of a protein to produce a large number of antibodies that will only bind to a specific protein. The antibodies can then be used to identify, count and track the proteins. Proteins are central to many areas of bioscience research as they are often the targets for vaccines, the raw materials for bioprocessing or are employed as environmental biomarkers. Production of panels of antibodies that previously took years may now be possible in just weeks.
Dr Rob Edwards, Imperial College Hammersmith Hospital, Tel: 020 8383 2055, e-mail:firstname.lastname@example.org
Building proteins on demand
A multidisciplinary team of researchers is developing new tools to direct the evolution of proteins, a move that will help the search for new anti-HIV drugs. The scientists have developed an efficient methodology for generating every possible mutation of a single protein and then assembling this into a library to identify which variations are resistant to drugs and which are not. This information can then be used to develop and validate new drugs.
Dr Cameron Neylon, University of Southampton, e-mail: email@example.com
Bringing physical forces to bear
World-leading laser facilities at the Rutherford Appleton Laboratory in Oxfordshire will be harnessed for biological studies thanks to joint funding from two Research Councils. A new laser system will study the bonds between atoms by looking at the unique frequency of their vibration. The new system will be able to take measurements of these ‘vibrational fingerprints’ at a scale so small that they will by able to study how cells repair damaged DNA, how proteins fold and develop new ways of detecting cancerous and pre-cancerous cells.
Professor Tony Parker, CCLRC Rutherford Appleton Laboratory, Tel: 01235 445109, e-mail: firstname.lastname@example.org
‘Model gut’ moves to commercialisation
Researchers at the Institute of Food Research in Norwich are moving closer to turning ten years of research on the workings of the human gut into a computer controlled model that will enable scientists to predict the digestive processes of human gut using real food and medicines. The result will be a revolutionary research tool that will enable researchers to examine the physical, chemical and biochemical functions of the gut as a whole.
Zoe Dunford, Institute of Food Research, Tel: 01603 255111, e-mail: email@example.com
The Biotechnology and Biological Sciences Research Council (BBSRC) is the UK funding agency for research in the life sciences. Sponsored by Government, BBSRC annually invests around £380 million in a wide range of research that makes a significant contribution to the quality of life for UK citizens and supports a number of important industrial stakeholders including the agriculture, food, chemical, healthcare and pharmaceutical sectors. http://www.bbsrc.ac.uk
5 November 2009
Scientists from the John Innes Centre in Norwich, UK and the University of Freiburg in Germany have uncovered a gene in plants that is responsible for controlling the size of seeds, which could lead to ways of improving crops to help ensure food security in the future.
Increasing seed or grain size has been key in the domestication of the crops used in modern agriculture, and with a growing world population, further increasing the yield of crops is one goal of agricultural research. Michael Lenhard, funded by the Biotechnology and Biological Sciences Research Council (BBSRC), has identified a gene in the model plant Arabidopsis that determines overall seed size, and is now investigating how this could be used to for the improvement of crops.
Publishing in the Proceedings of the National Academy of Sciences, the team from the John Innes Centre, an institute of the BBSRC, demonstrated that the gene acts locally at the base of the growing seed. It produces an as yet unidentified mobile growth signal that determines final seed size. If the gene is turned off, smaller seeds are produced, but crucially if the gene is turned on at a higher level than normal, seeds a third larger in size and weight are produced. This is the first time such a reciprocal effect on seed size has been observed, and points to the fundamental importance of this gene in plant development.
More work is now needed before this research can be applied to crop plants. One effect of increasing the seed size in the experimental plants was to decrease the total number of seeds produced, so there was no overall increase in yield. The scientists did notice an increase in the relative oil content of the larger seeds, so the effects of altering this gene in oil seed rape is currently being investigated.
Unravelling this gene’s role in determining the final seed size will also be important for other strategies for increasing yield, an example of how fundamental plant science can inform and drive efforts to ensure food security
Professor Mike Bevan, Acting Director of the John Innes Centre, said “This work shows how JIC's focus on understanding the mechanisms controlling plant growth can have immediate useful application for crop improvement.”
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Notes to editors
Reference: Local maternal control of seed size by KLUH/CYP78A5-dependent growth
Funding: BBSRC David Phillips Fellowship.
About the John Innes Centre
The John Innes Centre, www.jic.ac.uk, is an independent, world-leading research centre in plant and microbial sciences with over 800 staff. JIC is based on Norwich Research Park and carries out high quality fundamental, strategic and applied research to understand how plants and microbes work at the molecular, cellular and genetic levels. The JIC also trains scientists and students, collaborates with many other research laboratories and communicates its science to end-users and the general public. The JIC is grant-aided by the Biotechnology and Biological Sciences Research Council.
The Biotechnology and Biological Sciences Research Council (BBSRC) is the UK funding agency for research in the life sciences. Sponsored by Government, BBSRC annually invests around £450M in a wide range of research that makes a significant contribution to the quality of life for UK citizens and supports a number of important industrial stakeholders including the agriculture, food, chemical, healthcare and pharmaceutical sectors. BBSRC carries out its mission by funding internationally competitive research, providing training in the biosciences, fostering opportunities for knowledge transfer and innovation and promoting interaction with the public and other stakeholders on issues of scientific interest in universities, centres and institutes.
The Babraham Institute, Institute for Animal Health, Institute of Food Research, John Innes Centre and Rothamsted Research are Institutes of BBSRC. The Institutes conduct long-term, mission-oriented research using specialist facilities. They have strong interactions with industry, Government departments and other end-users of their research.
Andrew Chapple, John Innes Centre
tel: 01603 251490
Zoe Dunford, John Innes Centre
tel: 01603 255111