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Towards a universal avian influenza vaccine

4 December 2012

Researchers at The Pirbright Institute, which receives strategic funding from BBSRC, in collaboration with colleagues at the University of Oxford working together as the Jenner Institute, have taken an important step towards a universal vaccine against avian influenza. This virus disease threatens the £8 billion poultry industry in the UK and poses a risk of new human strains of flu. The research is published 'In Press' in the journal Vaccine.

Dr Colin Butter led the research, he said "Traditional avian flu vaccines are only effective against one particular type of flu but we want to be able to protect birds, and ultimately people, against different subtypes using just one vaccine. This research suggests that in principle a universal vaccine is possible."

Poultry meat is the most popular source of protein across the world and is increasingly in demand in the burgeoning economies of South and East Asia. With the global population set to reach 9 billion by 2050, food security is in jeopardy and improving poultry production by controlling disease will be a very important solution to this problem.

Avian influenza is a significant health and welfare issue in the poultry industry and avian strains can evolve to infect humans. The development of a universal vaccine for poultry could help strategies, also being pioneered by the Jenner Institute, to prevent seasonal flu or control any future pandemic in humans.

The team used a vaccine based on proteins from within a human flu virus, which was effective to initiate an immune response in chickens that would, in theory, protect against multiple strains of flu. It also reduced the extent to which birds shed live infectious virus that could further an outbreak of disease.

Dr Butter continued "We've found that by using proteins that are very similar in all flu viruses and delivering them packaged inside another harmless virus, we can safely vaccinate into eggs while the chick is still developing and then give a booster injection after hatch. This seems to be effective in priming the chicken's immune systems against a bird flu virus only distantly related to the human virus whose genes we used to make the vaccine."

The next stage of work will be to investigate how effective this strategy can be in preventing the spread of virus in birds. If it works well, it could play an important role in protecting both birds and humans from the scourge of a disease that is still a killer in both populations.

ENDS

Notes to editors

This research is published In Press as an uncorrected proof as follows: http://dx.doi.org/10.1016/j.vaccine.2012.11.047

Dr Colin Butter's research. More information as follows:  www.pirbright.ac.uk/research/aviVirImm and www.jenner.ac.uk/avianswineflu

Human influenza vaccine research at the Jenner Institute. More information: www.jenner.ac.uk/humanflu

About The Pirbright Institute

The Pirbright Institute is a world leading centre of excellence in research and surveillance of virus diseases of farm animals and viruses that spread from animals to humans. Based in the UK and receiving strategic funding from the Biotechnology and Biological Sciences Research Council (BBSRC), the Institute works to enhance capability to contain, control and eliminate these economically and medically important diseases through highly innovative fundamental and applied bioscience. With an annual income of over £25 million from grants and commercial activity, and a total of £76.9M strategic investment from BBSRC during 2011-12, the Institute contributes to global food security and health, improving quality of life for animals and people.

For more information see www.pirbright.ac.uk

About BBSRC

BBSRC invests in world-class bioscience research and training on behalf of the UK public. Our aim is to further scientific knowledge, to promote economic growth, wealth and job creation and to improve quality of life in the UK and beyond.

Funded by Government, and with an annual budget of around £500M (2012-2013), we support research and training in universities and strategically funded institutes. BBSRC research and the people we fund are helping society to meet major challenges, including food security, green energy and healthier, longer lives. Our investments underpin important UK economic sectors, such as farming, food, industrial biotechnology and pharmaceuticals.

For more information about BBSRC, our science and our impact see: www.bbsrc.ac.uk .
For more information about BBSRC strategically funded institutes see: www.bbsrc.ac.uk/institutes .

External contact

Nancy Mendoza, Head of Communications, The Pirbright Institute

tel: 01483 231154
mob: 07833 046405

Dave Cavanagh, Outreach Programme Manager, The Pirbright Institute

tel: 01635 577241
mob: 07733 307179