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Zebrafish study reveals clues to healing spinal cord injuries

Copyright: The University of Edinburgh
News from: The University of Edinburgh

Fresh insights into how zebrafish repair their nerve connections could hold clues to new therapies for people with spinal cord injuries.

Researchers have pinpointed key molecules that prompt damaged nerve fibres in the fish to regenerate themselves.

Copyright: The University of Edinburgh
Zebrafish nerve fibres (arrows) from the injured spinal cord (green) regrow into Collagen XII (red)-containing territory in a fully grown zebrafish. Copyright: The University of Edinburgh

The findings could pave the way for treatments that help restore vital connections between the brain and muscles of the body that are lost after spinal cord injury.

For people and other mammals, damage to the spinal cord is permanent and results in irreversible paralysis.

Zebrafish have the remarkable ability to regain full movement within four weeks of injury to their spinal cord.

Studies have shown that they are able to restore damaged connections and nerve cells in the spinal cord.

Scientists at The University of Edinburgh’s Centre for Neuroregeneration have pinpointed a key mechanism that helps the nerve connections to regrow.

They found that after injury, wound-healing cells called fibroblasts move into the site of damage.

These fibroblasts produce a molecule called collagen 12, which changes the structure of the support matrix that surrounds nerve fibres.

This enables the damaged fibres to grow back across the wound site and restore the lost connections.

The team found that fibroblasts are instructed to make collagen 12 by a chemical signal called wnt.

Understanding these signals could hold clues for therapies to help heal the spinal cord after injury, the researchers say.

The study, published in the journal Nature Communications, was funded by the Biotechnology and Biological Science Research Council and the National Centre for Reduction, Refinement and Replacement of Animals in Research. The German research funding organisation, DFG, also supported the research.

Copyright: The University of Edinburgh
A living zebrafish larva with brain and spinal cord fluorescing in red. Copyright: The University of Edinburgh

Lead researcher Professor Thomas Becker, Director of the Centre for Neuroregeneration at The University of Edinburgh, said: “In people and other mammals, the matrix in the injury site blocks nerves from growing back after an injury. We have now pinpointed the signals that remove this roadblock in zebrafish, so that nerve cells can repair connections that are lost after damage to the spinal cord.”

“We next plan to check whether triggering these signals in other animals can help them to repair nerve connections damaged by spinal cord injuries.”

ENDS

Notes to editors

Paper: Wnt signaling controls pro-regenerative Collagen XII in functional spinal cord regeneration in zebrafish - Daniel Wehner, Themistoklis M. Tsarouchas, Andria Michael, Christa Haase, Gilbert Weidinger, Michell M. Reimer, Thomas Becker and Catherina G. Becker. Nature Communications.


Header image: Collagen XII (green) accumulates in the injury site (arrow) of the spinal cord (red). Zebrafish nerve fibres have to grow through the Collagen XII to reconnect the spinal cord. Copyright: The University of Edinburgh.

External contact

Jen Middleton, Press and PR Office, The University of Edinburgh


0131 650 6514


Tags: health biology human health research press release