A major breakthrough by scientists at the University of Dundee in the study of a set of human proteins has the potential to unlock a huge new area of drug discovery for many diseases including cancer and inflammatory conditions. The research team led by Dr Alessio Ciulli in the College of Life Sciences at Dundee have developed a new method of selectively targeting the proteins known as BET bromodomains using small molecules.
Cancer Research UK scientists partly funded by BBSRC have discovered that melanoma cells are drawn to follow the ‘trail’ of a naturally-occurring molecule in the body, which directs this serious type of skin cancer to spread, according to research published in PLOS Biology. The team at the Cancer Research UK Beatson Institute at the University of Glasgow, revealed that melanoma cells give themselves the ‘green light’ to move using the molecule – a type of fatty chemical called lysophosphatidic acid (LPA).
Cholesterol-type molecules important in neuron survival and death. BBSRC funded scientists at Swansea University and Karolinska Institutet in Stockholm have identified two cholesterol-type molecules that play an important role in regulating the balance between survival and death…