Secrets of cell function could help quest for new medicines
22 March 2010
BBSRC-funded scientists have shed light on a key control process within cells that helps ensure our bodies function efficiently.
They have defined the shape of a protein molecule at different stages as it performs a key activity within a cell - breaking down sugar to turn it into energy.
The findings - which enable scientists to create graphics of the molecular structure at various stages of the process - could prove vital in informing the quest for new medicines.
Scientists hope that this initial development will lead them to gain insights into how the cells in our bodies function appropriately in response to changing needs.
Precisely how cells are regulated is a mystery which has puzzled scientists for decades. The findings help to pinpoint how cells control their activities, for example how our heart is able to pump faster when we climb stairs, or how our digestive system breaks down a big meal.
The way proteins communicate within a cell is known as the 'second secret of life' - its importance in explaining the science of living things is ranked by scientists as second only to the discovery of DNA.
Scientists reached their findings by studying a protein from the parasite that causes sleeping sickness, which may aid the search for treatments for the disease.
The study, carried out in collaboration with the de Duve Institute, Brussels, is published in the Journal of Biological Chemistry and funded by BBSRC, the Medical Research Council, the Wellcome Trust and the European Commission.
Professor Malcolm Walkinshaw, of the University of Edinburgh's School of Biological Sciences, who took part in the research, said: "While this study looked at a protein linked to sleeping sickness, the basic principle applies to all cells, including those in our bodies. This helps us understand how our organs work to perform everyday tasks according to the needs of our bodies, such as how our liver cells process toxins, or lung cells enable us to breathe."
BBSRC is the UK funding agency for research in the life sciences. Sponsored by Government, BBSRC annually invests around £450M in a wide range of research that makes a significant contribution to the quality of life in the UK and beyond and supports a number of important industrial stakeholders, including the agriculture, food, chemical, healthcare and pharmaceutical sectors.
BBSRC provides institute strategic research grants to the following:
- The Babraham Institute
- Institute for Animal Health
- Institute for Biological, Environmental and Rural Studies (Aberystwyth University)
- Institute of Food Research
- John Innes Centre
- The Genome Analysis Centre
- The Roslin Institute (University of Edinburgh)
- Rothamsted Research
The Institutes conduct long-term, mission-oriented research using specialist facilities. They have strong interactions with industry, Government departments and other end-users of their research.
Professor Malcolm Walkinshaw, School of Biological Sciences, The University of Edinburgh
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Catriona Kelly, The University of Edinburgh Press Office
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